316 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
This study identifies the coccidian-specific helical repeat protein mRSiC as an essential factor in *Toxoplasma gondii* that stabilizes mitochondrial sRNAs to ensure the accumulation of fragmented rRNAs, thereby supporting functional respiratory chain assembly and parasite proliferation.
PartiNet is a dynamic, size-agnostic AI framework for cryo-EM particle picking that accelerates inference up to 7-fold by adapting network complexity to micrograph quality, thereby eliminating manual parameter tuning while delivering superior precision, recall, and high-resolution structural reconstructions.
The paper introduces BiHiTo, a biomolecular hierarchy-inspired tokenizer that utilizes a multi-codebook quantizer to mimic natural structural assembly levels, achieving state-of-the-art performance in reconstructing and generating large-scale biomolecular structures with significantly improved accuracy and interpretability.
This study reveals that EZH2 drives melanoma metastasis through a non-canonical, methyltransferase-independent interaction with TRIM28 to upregulate the heparan sulfate-modifying enzyme SULF1, thereby remodeling the extracellular matrix to enhance cell migration and invasion.
This study demonstrates that in MCF7 breast cancer cells, the pro-inflammatory cytokine IL-1β enhances IGFL1 translation through a specific G-rich region within its 3' untranslated region, revealing a novel post-transcriptional regulatory mechanism in the inflammatory tumor microenvironment.
This study reveals that the antitoxin AbiEi neutralizes the nucleotidyltransferase toxin AbiEii by inducing its reversible auto-phosphorylation, thereby reclassifying the AbiE system as a Type VII toxin-antitoxin module that safeguards global translation in *Streptococcus agalactiae*.